Antihypertensive Drug Dosing
Cardiovascular drugs should usually be started around ED50, lower doses are safer and often sufficient, especially in combinations.
Effective dose 50%, ED50 = the mean population dose necessary to achieve half the maximum (Emax) possible drug effect. ED50 was estimated from published dose response data and based on reduction of BP (and with beta-blockers, HR) and thereby hopefully heart failure and other CV outcomes.
Correct Dosing In Relation To Hypertension Treatment And Maintenance
Website contributor, Professor Simon Dimmitt, was a guest on the podcast, This Medical Life. His appearance, on episode 23 entitled, Hypertension: Too Much Of A Good Thing?, provided the opportunity to discuss the concept of correct dosing in relation to hypertension…