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Is There Now Evidence For Rethinking Statin Dose?
Determining the best statin dose for a patient often appears challenging. Hitting the ‘sweet spot’, particularly with drugs that affect the brain, can provide enormous relief from symptoms. It is always be prudent to start a new drug with a low…
Statin dosing
Statin dosing can start and is usually sufficient around ED50.
Effective dose 50%, ED50 = the mean population dose necessary to achieve half the maximum (Emax) possible HMG CoA reductase inhibition. ED50 was estimated from published systematic reviews with dose response data of reductions in low density lipoprotein (LDL)-cholesterol and thereby hopefully coronary events.